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KMID : 0191120120270101162
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Journal of Korean Medical Science
2012 Volume.27 No. 10 p.1162 ~ p.1169
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Serum Thioredoxin 1 Level Has Close Relation with Myocardial Damage Amount in Acute Myocardial Infarction Patients
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Shim Young-Kwang
Kim Jeong-Tae
Seong Mun-Hyuk
Kim Yeon-Jeong
Shim Tae-Jin
Kim Sang-Min
Lee Sang-Yeub
Bae Jang-Whan
Kim Ki-Seok
Hwang Kyung-Kuk
Kim Dong-Woon
Cho Myeong-Chan
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Abstract
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Thioredoxin-1 (Trx-1) is one of important anti-oxidative molecules to overcome the oxidative stress. The aim of the present study is to investigate the clinical relationship between serum concentration of Trx-1 on the pre-percutaneous coronary intervention (prePCI) and myocardial damage amount in the patients with acute myocardial infarction with the culprit lesion in only the left anterior descending artery on coronary angiography (n = 100). Initial value of creatine kinase (CK) was 368.3 ± 531.4 U/L, and MB isoenzyme of CK (CK-MB) level was 22.92 ± 33.8 ng/mL, and cardiac specific troponin T (cTnT) level was 0.61 ± 1.6 ng/mL. Positive correlations were observed between prePCI Trx-1 level and initial CK (P = 0.005, r = 0.281), and cTnT (P < 0.001, r = 0.453), peak CK (P = 0.001, r = 0.316) in all patients, but the statistical relation was observed only in ST segment elevation myocardial infarction (STEMI) patients (P = 0.008, r = 0.329 for initial CK, P = 0.001, r = 0.498 for initial cTnT, P = 0.005, r = 0.349 for peak CK), not in Non-STEMI patients. Conclusively, we consider prePCI serum Trx-1 as a predictor for myocardial damage amount in patients with STEMI.
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KEYWORD
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Myocardial Infarction, Thioredoxins, Biochemical Markers, Oxidative Stress
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